Objective: To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS).
Methods: All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015.
Results: LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 with primary APS. Main complications in the four treatment groups (no anticoagulant treatment, aspirin, LMWH, aspirin and LMWH) included hypertensive disorders of pregnancy (9.4%, 23.3%, 50%, 18.4%, respectively, p = 0.12) and preterm birth (16.7%, 34.3%, 75%, 36.8%, respectively, p < 0.001).
Conclusion: Maternal and perinatal complications occurred frequently, despite LMWH and aspirin use.
Keywords: Antiphospholipid syndrome; aspirin; hypertensive disorders of pregnancy; low-molecular-weight heparin; systemic lupus erythematosus.