Aptamer-Based Screens of Human Body Fluids for Biomarkers

Microarrays (Basel). 2015 Sep 22;4(3):424-31. doi: 10.3390/microarrays4030424.


In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered.

Keywords: aptamer; biomarker; diagnostics; immunoassay; microarray.

Publication types

  • Review