Chronic binge alcohol administration impairs glucose-insulin dynamics and decreases adiponectin in asymptomatic simian immunodeficiency virus-infected macaques

Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R888-R897. doi: 10.1152/ajpregu.00142.2016. Epub 2016 Sep 7.


Alcohol use disorders (AUDs) frequently exist among persons living with HIV/AIDS. Chronic alcohol consumption, HIV infection, and antiretroviral therapy (ART) are independently associated with impairments in glucose-insulin dynamics. Previous studies from our laboratory have shown that chronic binge alcohol (CBA) administration decreases body mass index, attenuates weight gain, and accentuates skeletal muscle wasting at end-stage disease in non-ART-treated simian immunodeficiency virus (SIV)-infected male rhesus macaques. The aim of this study was to investigate whether CBA and ART alone or in combination alter body composition or glucose-insulin dynamics in SIV-infected male rhesus macaques during the asymptomatic phase of SIV infection. Daily CBA or sucrose (SUC) administration was initiated 3 mo before intrarectal SIV inoculation and continued until the study end point at 11 mo post-SIV infection. ART or placebo was initiated 2.5 mo after SIV infection and continued until study end point. Four treatment groups (SUC/SIV ± ART and CBA/SIV ± ART) were studied. CBA/SIV macaques had significantly decreased circulating adiponectin and resistin levels relative to SUC/SIV macaques and reduced disposition index and acute insulin response to glucose, insulin, and C-peptide release during frequently sampled intravenous glucose tolerance test, irrespective of ART status. No statistically significant differences were observed in homeostatic model assessment-insulin resistance values, body weight, total body fat, abdominal fat, or total lean mass or bone health among the four groups. These findings demonstrate CBA-mediated impairments in glucose-insulin dynamics and adipokine profile in asymptomatic SIV-infected macaques, irrespective of ART.

Keywords: SIV; Simian Immunodeficiency Virus; adiponectin; body composition; chronic alcohol; glucose-insulin dynamics.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adiponectin / blood*
  • Animals
  • Antiretroviral Therapy, Highly Active
  • Asymptomatic Diseases
  • Binge Drinking / complications
  • Binge Drinking / physiopathology*
  • Blood Glucose / metabolism*
  • Body Weight*
  • Chronic Disease
  • Insulin / blood*
  • Macaca mulatta
  • Male
  • Simian Acquired Immunodeficiency Syndrome / complications
  • Simian Acquired Immunodeficiency Syndrome / physiopathology*
  • Simian Acquired Immunodeficiency Syndrome / prevention & control
  • Treatment Outcome


  • Adiponectin
  • Blood Glucose
  • Insulin