68Ga-NODAGA-RGDyK PET/CT Imaging in Esophageal Cancer: First-in-Human Imaging

Clin Nucl Med. 2016 Nov;41(11):e491-e492. doi: 10.1097/RLU.0000000000001365.


Ga-NODAGA-RGDyK(cyclic) and FDG PET/CT were performed in a 39-year-old man for the work-up of a moderately differentiated carcinoma of the gastro-esophageal junction within a clinical study protocol. Although FDG PET images showed intense, diffuse hypermetabolic lesion activity, NODAGA-RGDyK illustrated the neo-angiogenesis process with tracer uptake clearly localized in non-FDG-avid perilesional structures. Neo-angiogenesis is characterized by ανβ3 integrin expression at the lesion surface of newly formed vessels. This case supports evidence that angiogenesis imaging might therefore be a crucial step in early disease identification and localization, metastatization potential, and in monitoring the efficacy of antiangiogenic therapies.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma / blood supply
  • Carcinoma / diagnostic imaging*
  • Coordination Complexes
  • Esophageal Neoplasms / blood supply
  • Esophageal Neoplasms / diagnostic imaging*
  • Esophagogastric Junction / blood supply
  • Esophagogastric Junction / diagnostic imaging*
  • Fluorodeoxyglucose F18
  • Humans
  • Male
  • Neovascularization, Pathologic / diagnostic imaging*
  • Peptides, Cyclic
  • Positron Emission Tomography Computed Tomography
  • Radiopharmaceuticals


  • Coordination Complexes
  • Peptides, Cyclic
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18