Diet-Intestinal Microbiota Axis in Osteoarthritis: A Possible Role

Mediators Inflamm. 2016;2016:3495173. doi: 10.1155/2016/3495173. Epub 2016 Aug 17.


Intestinal microbiota is highly involved in host physiology and pathology through activity of the microbiome and its metabolic products. Osteoarthritis (OA) is a common form of arthritis characterized by articular cartilage destruction and osteophyte formation. Although various person-level risk factors, such as age, sex, and obesity, have been proposed for the pathogenesis of OA, the underlying links between these person-level factors and OA are still enigmatic. Based on the current understanding in the crosstalk between intestinal microbiota and these risk factors, intestinal microbiota could be considered as a major hidden risk factor that provides a unifying mechanism to explain the involvement of these person-level risk factors in OA.

Publication types

  • Review

MeSH terms

  • Animals
  • Cartilage, Articular / microbiology*
  • Diet*
  • Female
  • Gastrointestinal Microbiome*
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity / complications
  • Osteoarthritis / complications
  • Osteoarthritis / microbiology
  • Osteoarthritis / physiopathology*
  • Risk Factors
  • Sex Factors