Probing the Diversity of T Cell Dysfunction in Cancer

Cell. 2016 Sep 8;166(6):1362-1364. doi: 10.1016/j.cell.2016.08.058.


T cell dysfunction in cancer comes in many forms, with two new varieties reported in this issue. Daley et al. find that T cells expressing γδ T cell receptors (TCR) promote pancreatic tumor growth by inhibiting activation of T cells with conventional TCRs. Singer et al. characterize dysfunctional tumor infiltrating lymphocytes to reveal a role for zinc homeostasis in anti-tumor immunity.

Publication types

  • Comment

MeSH terms

  • Humans
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Neoplasms / immunology*
  • Receptors, Antigen, T-Cell, gamma-delta / immunology*
  • T-Lymphocytes / immunology


  • Receptors, Antigen, T-Cell, gamma-delta