MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia

Magn Reson Med. 1989 May;10(2):246-55. doi: 10.1002/mrm.1910100209.


To detect abnormal regional myocardial coronary flow reserve, serial spin-echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium-DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium-enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 +/- 22% vs 78 +/- 29% above baseline, respectively; P less than 0.05). The percentage changes in gadolinium-enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93).

MeSH terms

  • Animals
  • Contrast Media*
  • Coronary Circulation / drug effects*
  • Coronary Disease / pathology
  • Coronary Disease / physiopathology*
  • Dipyridamole / administration & dosage*
  • Disease Models, Animal
  • Dogs
  • Gadolinium DTPA
  • Gadolinium*
  • Hyperemia / physiopathology*
  • Magnetic Resonance Imaging*
  • Organometallic Compounds*
  • Pentetic Acid*
  • Vasodilation / drug effects


  • Contrast Media
  • Organometallic Compounds
  • Dipyridamole
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA