To evaluate of the effect of adding licorice to the standard treatment regimen of Helicobacter pylori

Braz J Infect Dis. 2016 Nov-Dec;20(6):534-538. doi: 10.1016/j.bjid.2016.07.015. Epub 2016 Sep 8.


Objective: The aim of this study was to evaluate the effect of licorice in H. pylori eradication in patients suffering from dyspepsia either with peptic ulcer disease (PUD) or non-ulcer dyspepsia (NUD) in comparison to the clarithromycin-based standard triple regimen.

Methods: In this randomized controlled clinical trial, 120 patients who had positive rapid urease test were included and assigned to two treatment groups: control group that received a clarithromycin-based triple regimen, and study group that received licorice in addition to the clarithromycin-based regimen for two weeks. H. pylori eradication was assessed six weeks after therapy. Data was analyzed by chi-square and t-test with SPSS 16 software.

Results: Mean ages and SD were 38.8±10.9 and 40.1±10.4 for the study and control groups, respectively, statistically similar. Peptic ulcer was found in 30% of both groups. Response to treatment was 83.3% and 62.5% in the study and control groups, respectively. This difference was statistically significant.

Conclusion: Addition of licorice to the triple clarithromycin-based regimen increases H. pylori eradication, especially in the presence of peptic ulcer disease.

Keywords: Dyspepsia; Helicobacter pylori; Licorice; Peptic ulcer.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use*
  • Clarithromycin / therapeutic use*
  • Dyspepsia / drug therapy
  • Dyspepsia / microbiology
  • Female
  • Glycyrrhiza / chemistry*
  • Helicobacter Infections / drug therapy*
  • Helicobacter pylori / drug effects*
  • Humans
  • Male
  • Peptic Ulcer / drug therapy
  • Peptic Ulcer / microbiology
  • Plant Extracts / therapeutic use*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Plant Extracts
  • Clarithromycin