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Review
. 2016 Sep;18 Suppl 1:97-101.
doi: 10.1111/dom.12724.

Mechanisms of Adult Human β-Cell in Vitro Dedifferentiation and Redifferentiation

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Review

Mechanisms of Adult Human β-Cell in Vitro Dedifferentiation and Redifferentiation

S Efrat. Diabetes Obes Metab. .

Abstract

Recent studies in animal models and human pathological specimens suggest the involvement of β-cell dedifferentiation in β-cell dysfunction associated with type 2 diabetes. Dedifferentiated β-cells may be exploited for endogenous renewal of the β-cell mass. However, studying human β-cell dedifferentiation in diabetes presents major difficulties. We have analysed mechanisms involved in human β-cell dedifferentiation in vitro, under conditions that allow cell proliferation. Although there are important differences between the two cellular environments, β-cell dedifferentiation in the two conditions is likely to share a number of common pathways. Insights from the in vitro studies may lead to development of approaches for redifferentiation of endogenous dedifferentiated β-cells.

Keywords: cell-lineage tracing; signalling pathways; type 2 diabetes; β-cell proliferation.

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