Branch-Selective Hydroarylation: Iodoarene-Olefin Cross-Coupling

J Am Chem Soc. 2016 Oct 5;138(39):12779-12782. doi: 10.1021/jacs.6b08507. Epub 2016 Sep 21.


A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.