Cilia and Nuclear Pore Proteins: Pore No More?

Dev Cell. 2016 Sep 12;38(5):445-6. doi: 10.1016/j.devcel.2016.08.019.

Abstract

Nuclear pore proteins at the base of cilia were thought to regulate transport into cilia. In this issue of Developmental Cell, Del Viso et al. (2016) challenge this view, showing instead that pore proteins localize to ciliary basal bodies and that their perturbation leads to congenital heart disease.

Publication types

  • Comment

MeSH terms

  • Cilia / genetics
  • Cilia / metabolism*
  • Cilia / pathology
  • Heart Defects, Congenital / genetics
  • Heart Defects, Congenital / metabolism*
  • Heart Defects, Congenital / pathology
  • Humans
  • Nuclear Pore / metabolism
  • Nuclear Pore Complex Proteins / genetics
  • Nuclear Pore Complex Proteins / metabolism*
  • Protein Transport / genetics

Substances

  • Nuclear Pore Complex Proteins