Abstract
Nuclear pore proteins at the base of cilia were thought to regulate transport into cilia. In this issue of Developmental Cell, Del Viso et al. (2016) challenge this view, showing instead that pore proteins localize to ciliary basal bodies and that their perturbation leads to congenital heart disease.
Copyright © 2016. Published by Elsevier Inc.
MeSH terms
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Cilia / genetics
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Cilia / metabolism*
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Cilia / pathology
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Heart Defects, Congenital / genetics
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Heart Defects, Congenital / metabolism*
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Heart Defects, Congenital / pathology
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Humans
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Nuclear Pore / metabolism
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Nuclear Pore Complex Proteins / genetics
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Nuclear Pore Complex Proteins / metabolism*
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Protein Transport / genetics
Substances
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Nuclear Pore Complex Proteins