Abstract
When neutrophils infiltrate a site of inflammation, they have to stop at the right place to exert their effector function. In this issue of Developmental Cell, Wang et al. (2016) show that neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.
Copyright © 2016 Elsevier Inc. All rights reserved.
MeSH terms
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Cell Movement / genetics
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Chemotaxis, Leukocyte / genetics
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Humans
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Inflammation / genetics
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Inflammation / metabolism*
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Inflammation / pathology
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Neutrophils / metabolism*
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Reactive Oxygen Species / metabolism*
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TRPM Cation Channels / genetics
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TRPM Cation Channels / metabolism*
Substances
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Reactive Oxygen Species
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TRPM Cation Channels
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TRPM2 protein, human