A Radical Break: Restraining Neutrophil Migration

Dev Cell. 2016 Sep 12;38(5):448-50. doi: 10.1016/j.devcel.2016.08.017.

Abstract

When neutrophils infiltrate a site of inflammation, they have to stop at the right place to exert their effector function. In this issue of Developmental Cell, Wang et al. (2016) show that neutrophils sense reactive oxygen species via the TRPM2 channel to arrest migration at their target site.

Publication types

  • Comment

MeSH terms

  • Cell Movement / genetics
  • Chemotaxis, Leukocyte / genetics
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Neutrophils / metabolism*
  • Reactive Oxygen Species / metabolism*
  • TRPM Cation Channels / genetics
  • TRPM Cation Channels / metabolism*

Substances

  • Reactive Oxygen Species
  • TRPM Cation Channels
  • TRPM2 protein, human