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. 2016 Dec;10(4):355-360.
doi: 10.1007/s12079-016-0353-7. Epub 2016 Sep 14.

An Overview of the Oxytocin-Oxytocin Receptor Signaling Network

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Free PMC article

An Overview of the Oxytocin-Oxytocin Receptor Signaling Network

Oishi Chatterjee et al. J Cell Commun Signal. .
Free PMC article

Abstract

Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions. However, a well annotated map of oxytocin signaling pathway is currently lacking in the publicly available pathway resources. Therefore, we systematically curated the available signaling information of oxytocin from published literature and collated the data to develop a more complete map. We cataloged 66 molecules belonging to oxytocin signaling pathway, which included 9 protein-protein interactions, 39 post-translational modifications, 14 protein translocation events and 22 activation/inhibition events. Further, Oxytocin signaling network data is made freely available to academic fraternity by integrating this into NetPath ( http://www.netpath.org /), a freely available human signaling pathway resource developed previously by our group.

Keywords: G-protein coupled receptor; Gene expression; Herring bodies; Nociception; Osteoclastogenesis; Prostaglandins.

Conflict of interest statement

The author(s) declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A schematic representation of reactions induced by oxytocin. The pathway map depicts reactions induced by stimulatory action of OXT through OXTR. Reactions represented in map are protein-protein interaction, post-translational modification, activation/inhibition and gene/protein expression. Sites and residues for post translational modifications are also shown. Legend is provided for identification of different pathway reactions

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