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. 2016 Dec 15;63(12):1615-1618.
doi: 10.1093/cid/ciw636. Epub 2016 Sep 13.

Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

Ryan K Shields  1   2   3 , Brian A Potoski  1   4   2 , Ghady Haidar  1 , Binghua Hao  3 , Yohei Doi  1 , Liang Chen  5 , Ellen G Press  1 , Barry N Kreiswirth  5 , Cornelius J Clancy  1   3   6 , M Hong Nguyen  1   2   3
Affiliations

Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections

Ryan K Shields et al. Clin Infect Dis. .

Abstract

Thirty-seven carbapenem-resistant Enterobacteriaceae (CRE)-infected patients were treated with ceftazidime-avibactam. Clinical success and survival rates at 30 days were 59% (22/37) and 76% (28/37), respectively. In 23% (5/22) of clinical successes, CRE infections recurred within 90 days. Microbiologic failure rate was 27% (10/37). Ceftazidime-avibactam resistance was detected in 30% (3/10) of microbiologic failures.

Keywords: Klebsiella pneumoniae carbapenemase; carbapenem-resistant Enterobacteriaceae; ceftazidime-avibactam resistance.

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