Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?

Michael V Berridge; Remy T Schneider; Melanie J McConnell

doi:10.1016/j.cmet.2016.08.023

Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?

Cell Metab. 2016 Sep 13;24(3):376-378. doi: 10.1016/j.cmet.2016.08.023.

Authors

Michael V Berridge¹, Remy T Schneider², Melanie J McConnell³

Affiliations

¹ Malaghan Institute of Medical Research, Wellington 6012, New Zealand. Electronic address: mberridge@malaghan.org.nz.
² Malaghan Institute of Medical Research, Wellington 6012, New Zealand; Victoria University of Wellington, Wellington 6140, New Zealand.
³ Victoria University of Wellington, Wellington 6140, New Zealand.

PMID: 27626198
DOI: 10.1016/j.cmet.2016.08.023

Abstract

Intercellular mitochondrial transfer has been shown in tumor models, following lung injury and in xenotransplants of leukemic cells, but trafficking between cells in the brain remains unexplored. A suggestion that mitochondria move from astrocytes to neurons in a model of ischemia in a recent article in Nature by Hayakawa et al. (2016) should be interpreted with caution.

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MeSH terms

Astrocytes*
Brain
Brain Ischemia
Guilt
Humans
Mitochondria*
Neurons