Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Homotypic Tumors

Adv Mater. 2016 Nov;28(43):9581-9588. doi: 10.1002/adma.201602173. Epub 2016 Sep 15.

Abstract

A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells and elongated blood circulation, and displays highly cell-specific targeting of the homotypic primary tumor and metastases, with successful inhibition of the growth and lung metastasis of the breast cancer cells.

Keywords: biomimetic; cancer; chemotherapy; metastasis; nanoparticles; self-targeting.