Artefactual origin of biphasic cortical spike-LFP correlation

J Comput Neurosci. 2017 Feb;42(1):31-35. doi: 10.1007/s10827-016-0625-5. Epub 2016 Sep 14.


Electrophysiological data acquisition systems introduce various distortions into the signals they record. While such distortions were discussed previously, their effects are often not appreciated. Here I show that the biphasic shape of cortical spike-triggered LFP average (stLFP), reported in multiple studies, is likely an artefact introduced by high-pass filter of the neural data acquisition system when the actual stLFP has a single trough around the zero lag.

Keywords: Extracellular amplifier; Neural data acquisition; Neural probes; Phase distortion; Silicon probes.

MeSH terms

  • Artifacts
  • Cerebral Cortex / physiology
  • Electrophysiological Phenomena*
  • Humans
  • Models, Neurological*