Proteome complexity and the forces that drive proteome imbalance

Nature. 2016 Sep 15;537(7620):328-38. doi: 10.1038/nature19947.


The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy
  • Chromosome Aberrations
  • Gene Dosage
  • Homeostasis / drug effects
  • Humans
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism
  • Neoplasms / drug therapy
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Protein Biosynthesis / drug effects
  • Protein Transport
  • Proteome / genetics
  • Proteome / metabolism*
  • Ribosomes / drug effects
  • Ribosomes / metabolism


  • Multiprotein Complexes
  • Proteome