Radicals: Reactive Intermediates with Translational Potential

J Am Chem Soc. 2016 Oct 5;138(39):12692-12714. doi: 10.1021/jacs.6b08856. Epub 2016 Sep 26.


This Perspective illustrates the defining characteristics of free radical chemistry, beginning with its rich and storied history. Studies from our laboratory are discussed along with recent developments emanating from others in this burgeoning area. The practicality and chemoselectivity of radical reactions enable rapid access to molecules of relevance to drug discovery, agrochemistry, material science, and other disciplines. Thus, these reactive intermediates possess inherent translational potential, as they can be widely used to expedite scientific endeavors for the betterment of humankind.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Free Radicals / chemistry*
  • Oxidation-Reduction
  • Sulfinic Acids / chemistry


  • Free Radicals
  • Sulfinic Acids