Dairy, calcium, vitamin D and ovarian cancer risk in African-American women

Br J Cancer. 2016 Oct 25;115(9):1122-1130. doi: 10.1038/bjc.2016.289. Epub 2016 Sep 15.

Abstract

Background: No previous study has evaluated the associations of dairy products, lactose, calcium and vitamin D with the risk of ovarian cancer in African-American women, who are known to have high mortality from the disease, as well as to be at risk for calcium and vitamin D deficiency.

Methods: We evaluated these associations among 490 ovarian cancer cases and 656 age- and site-matched controls of African-American descent recruited into the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).

Results: An increased ovarian cancer risk was observed for whole milk consumption and lactose intake (highest quartile vs lowest: OR=1.97, 95% CI: 1.25-3.10;P-trend: 0.008). Calcium intake was associated with a decreased risk of ovarian cancer (OR=0.51, 95 CI%: 0.30-0.86; P-trend: 0.009), but vitamin D intake was not. Longer sun exposure in summer months was found to predict a lower risk (OR=0.71, 95% CI: 0.51-0.99; P-trend: 0.049).

Conclusions: Our findings suggest that a high-calcium, low-lactose diet, and sun exposure in summer months may reduce the risk of ovarian cancer in African-American women.

MeSH terms

  • Adult
  • African Americans / statistics & numerical data*
  • Aged
  • Calcium, Dietary / administration & dosage*
  • Case-Control Studies
  • Dairy Products / statistics & numerical data*
  • Female
  • Humans
  • Middle Aged
  • Nutrition Surveys
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / ethnology*
  • Ovarian Neoplasms / mortality
  • Risk Factors
  • United States / epidemiology
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / ethnology
  • Young Adult

Substances

  • Calcium, Dietary
  • Vitamin D