Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial

Int J Food Sci Nutr. 2017 Mar;68(2):249-255. doi: 10.1080/09637486.2016.1229760. Epub 2016 Sep 16.


Increased free radicals production due to hyperglycemia produces oxidative stress in patients with diabetes. Pomegranate juice (PJ) has antioxidant properties. This study was conducted to determine the effects of PJ consumption in oxidative stress in type 2 diabetic patients. This study was a randomized clinical trial performed on 60, 40-65 years old diabetic patients. The patients were randomly allocated either to PJ consumption group or control. Patients in PJ group consumed 200 ml of PJ daily for six weeks. Sex distribution and the mean age were not different between two groups. After six weeks intervention, oxidized LDL and anti-oxidized LDL antibodies decreased and total serum antioxidant capacity and arylesterase activity of paraoxonase increased significantly in the PJ-treated group compared to the control group. Our data have shown that six weeks supplementation of PJ could have favorable effects on oxidative stress in patients with type 2 diabetes (T2D).

Keywords: Pomegranate juice; cardiovascular disease; diabetes; oxidative stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antioxidants / analysis
  • Aryldialkylphosphatase / blood
  • Aryldialkylphosphatase / genetics
  • Aryldialkylphosphatase / metabolism
  • Body Mass Index
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Energy Intake
  • Female
  • Fruit / chemistry
  • Fruit and Vegetable Juices*
  • Humans
  • Lipoproteins, LDL / blood
  • Lythraceae*
  • Male
  • Middle Aged
  • Nutrition Assessment
  • Oxidative Stress / physiology*
  • Single-Blind Method


  • Antioxidants
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • Aryldialkylphosphatase
  • PON1 protein, human