Functional dissection of inhibitory microcircuits in the visual cortex

Neurosci Res. 2017 Mar:116:70-76. doi: 10.1016/j.neures.2016.09.003. Epub 2016 Sep 12.

Abstract

Cerebral cortex contains various types of GABAergic neurons exerting local inhibition. Although the number of GABAergic inhibitory neurons is much smaller than glutamatergic excitatory neurons, they show greater diversity in their morphological and physiological properties. Genetic markers for distinct sub-classes of GABAergic neurons have been identified, and technical advances achieved in the past few decades have brought about a demonstration of a unique function of each sub-class of GABAergic neurons in the cortex. In particular, visual processing in the cortex requires inhibitory function of various GABAergic neurons. Here, we summarize current understandings on the function of inhibitory neurons in the cortex, especially focusing on their roles in visual processing.

Keywords: Cortical microcircuit; GABAergic neurons; Inhibitory neurons; Orientation selectivity; Visual cortex; Visual processing.

Publication types

  • Review

MeSH terms

  • Action Potentials
  • Animals
  • GABAergic Neurons / physiology
  • Humans
  • Neural Inhibition
  • Visual Cortex / physiology*
  • Visual Perception / physiology