Health-related quality of life following treatment for extremity soft tissue sarcoma

J Surg Oncol. 2016 Dec;114(7):821-827. doi: 10.1002/jso.24424. Epub 2016 Sep 16.

Abstract

Background and objectives: The primary objective of this study was to estimate the change in health-related quality of life (HRQL) 1 year following treatment for extremity soft tissue sarcoma (STS), measured by the EQ-5D. Secondary objectives included determining clinical variables associated with HRQL at 1 year, estimating the proportion with a clinically important difference (CID) in HRQL, and evaluating variability within EQ-5D domains.

Methods: Patients over the age of 16 years, treated for a localized extremity STS, were included. The EQ-5D change score from pre-treatment to 1-year follow-up was determined. The association of clinical variables with EQ-5D scores was estimated using a linear regression model. The proportion of patients with a CID in HRQL score was determined. A vector analysis of the EQ-5D domains was undertaken.

Results: The mean EQ-5D change score was 0.02. Age, sex, disease status, and initial EQ-5D score were associated with EQ-5D score at 1 year. There was a CID improvement in 32% and a deterioration in 24%. The anxiety and depression domain demonstrated the most change between baseline and 1 year after treatment.

Conclusion: Most patients maintain a high level of HRQL following treatment for extremity STS. J. Surg. Oncol. 2016;114:821-827. © 2016 2016 Wiley Periodicals, Inc.

Keywords: health-related quality of life; patient reported outcome; soft tissue sarcoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Extremities / surgery*
  • Female
  • Follow-Up Studies
  • Health Status Indicators
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Patient Outcome Assessment
  • Quality of Life* / psychology
  • Retrospective Studies
  • Sarcoma / diagnosis
  • Sarcoma / psychology
  • Sarcoma / surgery*
  • Young Adult