Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury

Curr Protein Pept Sci. 2017;18(12):1195-1199. doi: 10.2174/1389203717666160909123135.

Abstract

In the past decade, rapid developments in stem cell studies have occurred. Researchers have confirmed the plasticity of bone marrow stem cells and the repair and regeneration effects of bone marrow hematopoietic stem cells on solid organs. These findings have suggested the possibility of using bone marrow stem cell mobilizers to repair and regenerate injured organs. Recent studies on the effects of granulocyte colony-stimulating factor (G-CSF) and Plerixafor (AMD3100) on mouse acute kidney injury models have confirmed that the use of bone marrow stem cell mobilizers may be an effective therapeutic measure. This paper summarizes studies describing the effects of G-CSF and AMD3100 on various acute kidney injury models over the past 10 years.

Keywords: Acute kidney injuries; bone marrow stem cells; granulocyte colony-stimulating factor; plerixafor.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / drug therapy*
  • Acute Kidney Injury / genetics
  • Acute Kidney Injury / immunology
  • Acute Kidney Injury / pathology
  • Animals
  • Benzylamines
  • Chemokine CXCL12 / genetics
  • Chemokine CXCL12 / immunology
  • Cyclams
  • Disease Models, Animal
  • Gene Expression Regulation / drug effects*
  • Granulocyte Colony-Stimulating Factor / pharmacology*
  • Hematopoietic Stem Cell Mobilization / methods*
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / drug effects*
  • Hematopoietic Stem Cells / immunology
  • Heterocyclic Compounds / pharmacology*
  • Humans
  • Kidney / drug effects
  • Kidney / immunology
  • Kidney / pathology
  • Matrix Metalloproteinase 9 / genetics
  • Matrix Metalloproteinase 9 / immunology
  • Mice
  • Receptors, CXCR4 / genetics
  • Receptors, CXCR4 / immunology
  • Signal Transduction

Substances

  • Benzylamines
  • CXCR4 protein, mouse
  • Chemokine CXCL12
  • Cxcl12 protein, mouse
  • Cyclams
  • Heterocyclic Compounds
  • Receptors, CXCR4
  • Granulocyte Colony-Stimulating Factor
  • Matrix Metalloproteinase 9
  • Mmp9 protein, mouse
  • plerixafor