Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.


In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. This Review discusses the possibility of exploiting the reprogrammed glucose metabolism for therapeutic approaches that selectively target cancer cells.

Publication types

  • Review

MeSH terms

  • Energy Metabolism
  • Glucose / metabolism*
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / therapy*


  • Glucose