T cells in Systemic Lupus Erythematosus

Curr Opin Immunol. 2016 Dec;43:32-38. doi: 10.1016/j.coi.2016.09.001. Epub 2016 Sep 13.

Abstract

Systemic Lupus Erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. Metabolic and functional alterations result in peripheral tolerance failures and biased differentiation of T cells into pro-inflammatory and B cell-helper phenotypes as well as the accumulation of disease-promoting memory T cells. Understanding these T cell alterations and their origins is necessary to develop more accurate patient classification systems and to discover new therapeutic targets.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoantibodies / biosynthesis
  • B-Lymphocytes / immunology
  • Cell Communication
  • Cell Differentiation
  • Cytokines / metabolism
  • Humans
  • Immune Tolerance
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Nephritis / immunology*
  • Molecular Targeted Therapy
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*
  • Th17 Cells / immunology*

Substances

  • Autoantibodies
  • Cytokines