Multifunctional biomaterial coatings: synthetic challenges and biological activity

Biol Chem. 2017 Jan 1;398(1):3-22. doi: 10.1515/hsz-2016-0204.


A controlled interaction of materials with their surrounding biological environment is of great interest in many fields. Multifunctional coatings aim to provide simultaneous modulation of several biological signals. They can consist of various combinations of bioactive, and bioinert components as well as of reporter molecules to improve cell-material contacts, prevent infections or to analyze biochemical events on the surface. However, specific immobilization and particular assembly of various active molecules are challenging. Herein, an overview of multifunctional coatings for biomaterials is given, focusing on synthetic strategies and the biological benefits by displaying several motifs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology
  • Chemistry Techniques, Synthetic / methods*
  • Click Chemistry
  • Humans
  • Surface Properties


  • Biocompatible Materials