Role of Metabolomics in Traumatic Brain Injury Research

Stephanie M Wolahan; Daniel Hirt; Daniel Braas; Thomas C Glenn

doi:10.1016/j.nec.2016.05.006

Role of Metabolomics in Traumatic Brain Injury Research

Neurosurg Clin N Am. 2016 Oct;27(4):465-72. doi: 10.1016/j.nec.2016.05.006. Epub 2016 Aug 10.

Authors

Stephanie M Wolahan¹, Daniel Hirt¹, Daniel Braas², Thomas C Glenn³

Affiliations

¹ UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Neurosurgery, David Geffen School of Medicine at UCLA, 300 Stein Plaza, Los Angeles, CA 90095-6901, USA.
² Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 570 Westwood Plaza, Los Angeles, CA 90095-1735, USA; UCLA Metabolomics and Proteomics Center, 570 Westwood Plaza, University of California, Los Angeles, Los Angeles, CA 90095, USA.
³ UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Neurosurgery, David Geffen School of Medicine at UCLA, 300 Stein Plaza, Los Angeles, CA 90095-6901, USA. Electronic address: TGlenn@mednet.ucla.edu.

Abstract

Metabolomics is an important member of the omics community in that it defines which small molecules may be responsible for disease states. This article reviews the essential principles of metabolomics from specimen preparation, chemical analysis, to advanced statistical methods. Metabolomics in traumatic brain injury has so far been underutilized. Future metabolomics-based studies focused on the diagnoses, prognoses, and treatment effects need to be conducted across all types of traumatic brain injury.

Keywords: Biomarkers; Metabolism; Principal component analysis; Small molecules; Spectroscopy.

Publication types

Review

MeSH terms

Brain Injuries, Traumatic / diagnostic imaging
Brain Injuries, Traumatic / metabolism*
Chromatography, Gas
Chromatography, Liquid
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Metabolomics*
Research*

Abstract

Publication types

MeSH terms

Grant support