Role of Metabolomics in Traumatic Brain Injury Research

Neurosurg Clin N Am. 2016 Oct;27(4):465-72. doi: 10.1016/ Epub 2016 Aug 10.


Metabolomics is an important member of the omics community in that it defines which small molecules may be responsible for disease states. This article reviews the essential principles of metabolomics from specimen preparation, chemical analysis, to advanced statistical methods. Metabolomics in traumatic brain injury has so far been underutilized. Future metabolomics-based studies focused on the diagnoses, prognoses, and treatment effects need to be conducted across all types of traumatic brain injury.

Keywords: Biomarkers; Metabolism; Principal component analysis; Small molecules; Spectroscopy.

Publication types

  • Review

MeSH terms

  • Brain Injuries, Traumatic / diagnostic imaging
  • Brain Injuries, Traumatic / metabolism*
  • Chromatography, Gas
  • Chromatography, Liquid
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Metabolomics*
  • Research*