Trials without tribulations: Minimizing the burden of pragmatic research on healthcare systems

Healthc (Amst). 2016 Sep;4(3):138-41. doi: 10.1016/j.hjdsi.2015.07.005. Epub 2015 Jul 29.


Pragmatic clinical trials are increasingly common because they have the potential to yield findings that are directly translatable to real-world healthcare settings. Pragmatic clinical trials need to integrate research into clinical workflow without placing an undue burden on the delivery system. This requires a research partnership between investigators and healthcare system representatives. This paper, organized as a series of case studies drawn from our experience in the NIH Health Care Systems Research Collaboratory, presents guidance from informational interviews of physician-scientists, health services researchers, and delivery system leaders who recently launched pragmatic clinical trials.

Keywords: Pragmatic trials.

MeSH terms

  • Cooperative Behavior
  • Delivery of Health Care
  • Health Services Research / methods*
  • Humans
  • Pragmatic Clinical Trials as Topic / economics*
  • Pragmatic Clinical Trials as Topic / standards*
  • Research Design / standards*
  • United States