Genetics of Takotsubo Syndrome

Heart Fail Clin. 2016 Oct;12(4):499-506. doi: 10.1016/j.hfc.2016.06.007.

Abstract

Takotsubo syndrome (TTS) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. A genetic predisposition has been suggested based on the few familial TTS cases. Conflicting results have been published regarding the role of functional polymorphisms in relevant candidate genes, such as α1-, β1-, and β2-adrenergic receptors; G protein-coupled receptor kinase 5; and estrogen receptors. Further research is required to help clarify the role of genetic susceptibility in TTS.

Keywords: Adrenoceptor polymorphisms; Catecholamine-induced myocardial toxicity; Takotsubo syndrome.

Publication types

  • Review

MeSH terms

  • G-Protein-Coupled Receptor Kinase 5 / genetics
  • Genetic Predisposition to Disease
  • Humans
  • Polymorphism, Genetic
  • Receptors, Adrenergic, alpha-1 / genetics
  • Receptors, Adrenergic, beta-1 / genetics
  • Receptors, Adrenergic, beta-2 / genetics
  • Takotsubo Cardiomyopathy / genetics*
  • Takotsubo Cardiomyopathy / pathology

Substances

  • ADRA1A protein, human
  • ADRB1 protein, human
  • ADRB2 protein, human
  • Receptors, Adrenergic, alpha-1
  • Receptors, Adrenergic, beta-1
  • Receptors, Adrenergic, beta-2
  • G-Protein-Coupled Receptor Kinase 5
  • GRK5 protein, human