Neurodevelopmental disorder associated with prenatal exposure to alcohol (ND-PAE): A proposed diagnostic method of capturing the neurocognitive phenotype of FASD

Eur J Med Genet. 2017 Jan;60(1):49-54. doi: 10.1016/j.ejmg.2016.09.013. Epub 2016 Sep 13.

Abstract

Neurobehavioral Disorder associated with Prenatal Alcohol Exposure (ND-PAE) was proposed as a diagnostic formulation intended to capture the range of mental health problems occurring in alcohol-affected individuals with a history of prenatal alcohol exposure. The proposed criteria for the disorder are reviewed as well as various factors considered in the development of the disorder and its associated criteria. The taxonomic research related to the disorder is reviewed with preliminary analyses indicating that clinicians are readily able to agree when applying the diagnostic criteria but that the adaptive functioning criteria may need to be modified to expand its coverage of alcohol-affected individuals and to aid in discriminating these individuals from others not alcohol-affected. Finally, the challenges with translating the diagnosis into European medical and mental healthcare systems are discussed and recommendations for facilitating implementation are made.

Keywords: Fetal alcohol spectrum disorders; Mental health; ND-PAE; Psychiatric diagnosis.

Publication types

  • Review

MeSH terms

  • Alcohols / toxicity*
  • Female
  • Fetal Alcohol Spectrum Disorders / diagnosis
  • Fetal Alcohol Spectrum Disorders / epidemiology
  • Fetal Alcohol Spectrum Disorders / pathology
  • Humans
  • Mental Health*
  • Neurodevelopmental Disorders / chemically induced
  • Neurodevelopmental Disorders / diagnosis
  • Neurodevelopmental Disorders / epidemiology*
  • Neurodevelopmental Disorders / pathology
  • Phenotype
  • Pregnancy
  • Prenatal Exposure Delayed Effects / chemically induced
  • Prenatal Exposure Delayed Effects / diagnosis
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Prenatal Exposure Delayed Effects / pathology

Substances

  • Alcohols