Interleukin-33 in Health and Disease

Nat Rev Immunol. 2016 Nov;16(11):676-689. doi: 10.1038/nri.2016.95. Epub 2016 Sep 19.

Abstract

Interleukin-33 (IL-33) - a member of the IL-1 family - was originally described as an inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now, evidence is accumulating that IL-33 also potently stimulates group 2 innate lymphoid cells (ILC2s), regulatory T (Treg) cells, TH1 cells, CD8+ T cells and natural killer (NK) cells. This pleiotropic nature is reflected in the role of IL-33 in tissue and metabolic homeostasis, infection, inflammation, cancer and diseases of the central nervous system. In this Review, we highlight the molecular and cellular characteristics of IL-33, together with its major role in health and disease and the potential therapeutic implications of these findings in humans.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Central Nervous System / immunology
  • Central Nervous System / metabolism
  • Cytokines / metabolism
  • Disease Susceptibility
  • Gene Expression Regulation*
  • Humans
  • Immunity, Innate
  • Immunomodulation*
  • Inflammation / etiology
  • Inflammation / metabolism
  • Interleukin-33 / chemistry
  • Interleukin-33 / genetics*
  • Interleukin-33 / metabolism*
  • Neoplasms / etiology
  • Neoplasms / metabolism
  • Organ Transplantation
  • Regeneration / genetics
  • Regeneration / immunology
  • Signal Transduction*
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism

Substances

  • Cytokines
  • Interleukin-33