Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice

Pharmacol Res. 2016 Nov;113(Pt A):376-383. doi: 10.1016/j.phrs.2016.09.005. Epub 2016 Sep 15.


Bisphenol A is an environment-polluting industrial chemical able to interfere with the endocrine system. An obesogenic effect in perinatally exposed rodents has been described as estrogenic activity. We exposed male mice to Bisphenol A during fetal-perinatal period (from 10 days post coitum to 31 days post partum) and investigated the effects of this early-life exposure at 78 days of age. Body weight, food intake, fat mass, and hypothalamic signals related to anorexigenic control of food intake were analyzed. Results show that Bisphenol A exposure reduced body weight and food intake. In addition, the exposure decreased epididymal fat mass and adiposity, acting negatively on adipocyte volume. At hypothalamic level, Bisphenol A exposure reduced the expression of the cannabinoid receptor 1 and induced gene expression of cocaine and amphetamine-regulated transcript-1. This observation suggests that Bisphenol A induces activation of anorexigenic signals via down-regulation of the hypothalamic cannabinoid receptor 1 with negative impact on food intake.

Keywords: BPA; CB1 receptor; Estrogens; Food intake; Hypothalamus; POMC/CART anorexigenic signals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / drug effects
  • Adipocytes / metabolism
  • Adiposity / drug effects
  • Animals
  • Appetite Depressants / pharmacology*
  • Benzhydryl Compounds / pharmacology*
  • Body Weight / drug effects
  • Cannabinoids / metabolism*
  • Down-Regulation / drug effects*
  • Eating / drug effects
  • Gene Expression / drug effects
  • Hypothalamus / drug effects*
  • Hypothalamus / metabolism
  • Male
  • Mice
  • Phenols / pharmacology*
  • Receptor, Cannabinoid, CB1 / metabolism*


  • Appetite Depressants
  • Benzhydryl Compounds
  • Cannabinoids
  • Cnr1 protein, rat
  • Phenols
  • Receptor, Cannabinoid, CB1
  • bisphenol A