Radioiodination for therapy

Ann Clin Biochem. 1989 May;26 ( Pt 3):244-5. doi: 10.1177/000456328902600306.

Abstract

A method for the radioiodination of antibodies for therapy is described. The method resulted in a high efficiency of labelling (88-94%) with negligible damage to the antibody. Good localisation of labelled antibody was demonstrated. Doses of radiation to operators were very low.

MeSH terms

  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / therapeutic use*
  • Bromosuccinimide
  • Drug Carriers
  • Environmental Exposure
  • Humans
  • Immunotherapy / methods*
  • Iodine Radioisotopes / therapeutic use*
  • Liver Neoplasms / immunology
  • Liver Neoplasms / radiotherapy

Substances

  • Antibodies, Monoclonal
  • Drug Carriers
  • Iodine Radioisotopes
  • Bromosuccinimide