Effects of idebenone on lipid peroxidation and hemolysis in erythrocytes of stroke-prone spontaneously hypertensive rats

Arch Gerontol Geriatr. 1989 May;8(3):307-11. doi: 10.1016/0167-4943(89)90012-5.


Stroke-prone spontaneously hypertensive rats (SHRSP) were kept on a 1% NaCl solution as drinking water to shorten the onset-time of a stroke. The level of lipoperoxide (LPO) in the erythrocytes of SHRSP loaded with salt for 22 days was significantly higher than that of the controls. Idebenone treatment (30 mg/kg per day, p.o.) markedly decreased the LPO to the level of the controls. Hemolysis in SHRSP was accelerated by the salt-loading. Idebenone significantly inhibited the hemolysis in a dose-dependent manner. These results suggest that idebenone inhibits lipid peroxidation in erythrocytes and stabilizes the erythrocyte membrane.

MeSH terms

  • Animals
  • Benzoquinones*
  • Cerebrovascular Disorders / blood*
  • Erythrocytes / metabolism*
  • Hemolysis / drug effects*
  • Hypertension / blood
  • Lipid Peroxidation / drug effects*
  • Male
  • Quinones / pharmacology*
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Ubiquinone / analogs & derivatives


  • Benzoquinones
  • Quinones
  • Ubiquinone
  • idebenone