Subchronic Arsenic Exposure Through Drinking Water Alters Lipid Profile and Electrolyte Status in Rats

Biol Trace Elem Res. 2017 Apr;176(2):350-354. doi: 10.1007/s12011-016-0851-8. Epub 2016 Sep 19.


Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. On the 91st day, rats were sacrificed and blood was collected. Lipid profile and the levels of electrolytes (sodium, potassium, and chloride) were assessed in plasma. Arsenic reduced high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio, but increased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and electrolytes. The results suggest that the arsenic-mediated dyslipidemia and electrolyte retention could be important mechanisms in the arsenic-induced vascular disorder.

Keywords: Aorta; Arsenic; Lipid profile; Rats.

MeSH terms

  • Animals
  • Arsenites / administration & dosage
  • Arsenites / analysis
  • Arsenites / pharmacology*
  • Chlorides / blood*
  • Drinking Water / chemistry*
  • Electrolytes / blood*
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / pathology
  • Lipids / blood*
  • Male
  • Potassium / blood*
  • Rats
  • Rats, Wistar
  • Sodium / blood*
  • Sodium Compounds / administration & dosage
  • Sodium Compounds / analysis
  • Sodium Compounds / pharmacology*


  • Arsenites
  • Chlorides
  • Drinking Water
  • Electrolytes
  • Lipids
  • Sodium Compounds
  • sodium arsenite
  • Sodium
  • Potassium