Immunopathology alters Th17 cell glucocorticoid sensitivity

Allergy. 2017 Mar;72(3):331-341. doi: 10.1111/all.13051. Epub 2016 Oct 13.

Abstract

Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

Keywords: Th17 cells; asthma; autoimmunity; glucocorticoid resistance; glucocorticoids.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / metabolism
  • Anti-Inflammatory Agents / pharmacology*
  • Cell Differentiation / immunology
  • Cytokines / metabolism
  • Disease Susceptibility
  • Drug Tolerance*
  • Gene Expression Regulation
  • Glucocorticoids / pharmacology*
  • Glucocorticoids / therapeutic use
  • Humans
  • Immune System Diseases / drug therapy
  • Immune System Diseases / genetics
  • Immune System Diseases / immunology
  • Immune System Diseases / metabolism
  • Inflammation / drug therapy
  • Inflammation / genetics
  • Inflammation / immunology
  • Inflammation / metabolism
  • Signal Transduction
  • T-Lymphocyte Subsets / drug effects
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / metabolism
  • Th17 Cells / cytology
  • Th17 Cells / drug effects*
  • Th17 Cells / immunology*
  • Th17 Cells / metabolism

Substances

  • Anti-Inflammatory Agents
  • Cytokines
  • Glucocorticoids