Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population

Hypertens Pregnancy. 2016 Nov;35(4):565-572. doi: 10.1080/10641955.2016.1211677. Epub 2016 Sep 19.

Abstract

Objective: Previous studies have been indicated that catechol-O-methyltransferase gene (COMT) might play a significant role in the development of preeclampsia (PE). Our study aims to investigate the association between polymorphism in COMT with the susceptibility to PE in Chinese Han women.

Method: A total of 1028 PE patients and 1399 normal pregnant women were enrolled. We detected the genotyping of COMT Val158Met loci by the TaqMan allelic discrimination real-time PCR .

Results: No significant difference in the genotypic and allelic distribution was found between the two groups (genotype: X2 = 0.583, p = 0.747; allele:X2 = 0.526, p = 0.468).

Conclusion: The COMT Val158Met polymorphism might not be associated with PE in Chinese women.

Keywords: COMT; polymorphism; preeclampsia; val158Met(rs4680).

MeSH terms

  • Adult
  • Alleles
  • Asian People / genetics
  • Catechol O-Methyltransferase / genetics*
  • China
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease*
  • Genotype*
  • Humans
  • Polymorphism, Single Nucleotide*
  • Pre-Eclampsia / genetics*
  • Pregnancy

Substances

  • COMT protein, human
  • Catechol O-Methyltransferase