Increased prenatal blood manganese may induce gestational blood pressure

Hypertens Pregnancy. 2016 Nov;35(4):583-592. doi: 10.1080/10641955.2016.1219364. Epub 2016 Sep 20.


Objective: Pregnancy hypertension is the most common gestational complication and poses a critical risk for mother and fetus. Whether environmental factors may play an important role in disease occurrence is not fully determined.

Methods: To investigate the effects of prenatal manganese (Mn) exposure on gestational blood pressure, 386 women were examined.

Results: Early pregnancy blood Mn was significantly (p < 0.05) correlated with blood pressure through gestation. A significant association between odds of pre-hypertension with blood Mn was shown (OR:1.150, 95% CI:1.052-1.258).

Conclusion: The current study results might suggest the blood Mn level during early stage of pregnancy as a potential risk factor for increasing the risk of gestational blood pressure.

Keywords: Manganese; blood pressure; pre-hypertension; pregnancy; prenatal.

MeSH terms

  • Adult
  • Blood Pressure / drug effects*
  • Blood Pressure / physiology
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / etiology*
  • Female
  • Humans
  • Manganese / blood
  • Manganese / toxicity*
  • Maternal Exposure / adverse effects*
  • Pregnancy


  • Manganese