Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2016 Nov;37:94-100.
doi: 10.1016/j.jnutbio.2016.07.015. Epub 2016 Aug 26.

Effects of Hydroxytyrosol on Cardiovascular Biomarkers in Experimental Diabetes Mellitus

Affiliations
Comparative Study

Effects of Hydroxytyrosol on Cardiovascular Biomarkers in Experimental Diabetes Mellitus

Juan Antonio López-Villodres et al. J Nutr Biochem. .

Abstract

The aim of this study was to assess the influence of hydroxytyrosol (HT) on cardiovascular biomarkers and morphometric parameters of the arterial wall in streptozotocin-diabetic rats. Seven groups of rats (N=10 per group) were studied for 2 months: nondiabetic rats (NDR), diabetic rats treated with saline (DR) and DR treated with HT (0.5, 1, 2.5, 5 and 10 mg kg-1 day-1 p.o.). DR had higher platelet aggregation values, higher thromboxane B2, plasma lipid peroxidation, 3-nitrotyrosine, oxidized LDL (oxLDL), myeloperoxidase, vascular cell adhesion molecule 1 (VCAM-1) and interleukin-1β (IL-1β) concentrations, and lower aortic 6-keto-prostaglandin F and nitric oxide production than NDR. Aortic wall area and smooth muscle cell count were also higher in DR than in NDR. HT significantly reduced both oxidative and nitrosative stress, oxLDL concentration, VCAM-1 and inflammatory mediators, platelet aggregation and thromboxane B2 production. Morphometric values in the aortic wall were reduced to values near those in NDR. In conclusion, HT influenced the major biochemical processes leading to diabetic vasculopathy, and reduced cell proliferation in the vascular wall in this experimental model.

Keywords: Diabetes; Hydroxytyrosol; Inflammatory mediators; Oxidative stress; Platelets; Vasculopathy.

Similar articles

See all similar articles

Cited by 5 articles

Publication types

MeSH terms

Feedback