Abstract
The N-terminal region of the Streptomyces K15 DD-peptidase/penicillin-binding protein shows high homology with that of other penicillin-interactive proteins or domains. The active-site serine residue of the conserved tetrad Ser-Xaa-Xaa-Lys occurs at position 35. There is no indication for the presence of a signal peptide or an N-terminal hydrophobic sequence, suggesting that the Streptomyces K15 enzyme is probably anchored to the membrane by a C-terminal peptide segment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins*
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Binding Sites
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Carrier Proteins*
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Hexosyltransferases*
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Molecular Sequence Data
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Muramoylpentapeptide Carboxypeptidase*
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Penicillin-Binding Proteins
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Penicillins
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Peptide Fragments
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Peptidyl Transferases*
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Streptomyces / enzymology*
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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Penicillins
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Peptide Fragments
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase