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. 2016 Sep 20;7(5):e01154-16.
doi: 10.1128/mBio.01154-16.

Adenovirus Early Proteins and Host Sumoylation

Free PMC article

Adenovirus Early Proteins and Host Sumoylation

Sook-Young Sohn et al. mBio. .
Free PMC article


The human adenovirus genome is transported into the nucleus, where viral gene transcription, viral DNA replication, and virion assembly take place. Posttranslational modifications by small ubiquitin-like modifiers (SUMOs) are implicated in the regulation of diverse cellular processes, particularly nuclear events. It is not surprising, therefore, that adenovirus modulates and utilizes the host sumoylation system. Adenovirus early proteins play an important role in establishing optimal host environments for virus replication within infected cells by stimulating the cell cycle and counteracting host antiviral defenses. Here, we review findings on the mechanisms and functional consequences of the interplay between human adenovirus early proteins and the host sumoylation system.


Schematic overview of the interplay between Ad early proteins and the host sumoylation system. (A) E1A directly binds to SUMO E2 enzyme Ubc9 and inhibits SUMO-1 conjugation to pRb. (B) E1B-55K is a SUMO substrate and an E3 ligase for p53 and Sp100A. (C) E4-ORF3 functions as a SUMO E3 ligase and an E4 elongase. E4-ORF3 triggers sumoylation of multiple host proteins and subsequent proteasomal degradation of some of the target proteins. S, SUMO.

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    1. Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG. 1953. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Exp Biol Med 84:570–573. doi:10.3181/00379727-84-20714. - DOI - PubMed
    1. Hage E, Gerd Liebert U, Bergs S, Ganzenmueller T, Heim A. 2015. Human mastadenovirus type 70: a novel, multiple recombinant species D mastadenovirus isolated from diarrhoeal faeces of a haematopoietic stem cell transplantation recipient. J Gen Virol 96:2734–2742. doi:10.1099/vir.0.000196. - DOI - PubMed
    1. Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung’u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O’Connor KC, Walker B, Larman HB, Elledge SJ. 2015. Comprehensive serological profiling of human populations using a synthetic human virome. Science 348:aaa0698. doi:10.1126/science.aaa0698. - DOI - PMC - PubMed
    1. Lion T. 2014. Adenovirus infections in immunocompetent and immunocompromised patients. Clin Microbiol Rev 27:441–462. doi:10.1128/CMR.00116-13. - DOI - PMC - PubMed
    1. Berget SM, Moore C, Sharp PA. 1977. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc Natl Acad Sci U S A 74:3171–3175. doi:10.1073/pnas.74.8.3171. - DOI - PMC - PubMed

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