Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):516-531. doi: 10.1002/psp4.12134. Epub 2016 Oct 19.


The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic steps in PBPK model building, a PBPK model for ciprofloxacin will be constructed and coupled to a pharmacodynamic model to simulate the antibacterial activity of ciprofloxacin treatment.

MeSH terms

  • Animals
  • Computer Simulation
  • Humans
  • Models, Biological*
  • Pharmacokinetics*
  • Risk Assessment
  • Tissue Distribution