Hemodynamic Effect of Different Doses of Fluids for a Fluid Challenge: A Quasi-Randomized Controlled Study

Crit Care Med. 2017 Feb;45(2):e161-e168. doi: 10.1097/CCM.0000000000002067.


Objective: The objectives of this study are to determine what is the minimal volume required to perform an effective fluid challenge and to investigate how different doses of IV fluids in an fluid challenge affect the changes in cardiac output and the proportion of responders and nonresponders.

Design: Quasi-randomized controlled trial.

Setting: Cardiothoracic ICU, tertiary university hospital.

Patients: Eighty postcardiac surgery patients.

Intervention: IV infusion of 1, 2, 3, or 4 mL/Kg (body weight) of crystalloid over 5 minutes.

Measurements and main results: Mean systemic filling pressure measured using the transient stop-flow arm arterial-venous equilibrium pressure, arterial and central venous pressure, cardiac output (LiDCOplus; LiDCO, Cambridge, United Kingdom), and heart rate. The groups were well matched with respect to demographic and baseline physiologic variables. The proportion of responders increased from 20% in the group of 1 mL/kg to 65% in the group of 4 mL/kg (p = 0.04). The predicted minimal volume required for an fluid challenge was between 321 and 509 mL. Only 4 mL/Kg increases transient stop-flow arm arterial-venous equilibrium pressure beyond the limits of precision and was significantly associated with a positive response (odds ratio, 7.73; 95% CI, 1.78-31.04).

Conclusion: The doses of fluids used for an fluid challenge modify the proportions of responders in postoperative patients. A dose of 4 mL/Kg increases transient stop-flow arm arterial-venous equilibrium pressure and reliably detects responders and nonresponders.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Cardiac Output / drug effects
  • Cardiac Output / physiology
  • Crystalloid Solutions
  • Dose-Response Relationship, Drug
  • Female
  • Fluid Therapy / methods*
  • Heart Rate / drug effects
  • Heart Rate / physiology
  • Hemodynamics / drug effects*
  • Hemodynamics / physiology
  • Humans
  • Infusions, Intravenous
  • Isotonic Solutions / administration & dosage*
  • Isotonic Solutions / therapeutic use
  • Male
  • Middle Aged
  • Rehydration Solutions / administration & dosage*
  • Rehydration Solutions / therapeutic use
  • Single-Blind Method


  • Crystalloid Solutions
  • Isotonic Solutions
  • Rehydration Solutions