Life-Course Body Mass Index Trajectories Are Predicted by Childhood Socioeconomic Status but Not Exposure to Improved Nutrition during the First 1000 Days after Conception in Guatemalan Adults

J Nutr. 2016 Nov;146(11):2368-2374. doi: 10.3945/jn.116.236075. Epub 2016 Sep 21.

Abstract

Background: Latin America has experienced increases in obesity. Little is known about the role of early life factors on body mass index (BMI) gain over the life course.

Objective: The objective of this research was to examine the role of early life factors [specifically, nutrition supplementation during the first 1000 d (from conception to 2 y of age) and childhood household socioeconomic status (SES)] on the pattern of BMI gain from birth or early childhood through midadulthood by using latent class growth analysis.

Methods: Study participants (711 women, 742 men) who were born in 4 villages in Guatemala (1962-1977) were followed prospectively since participating in a randomized nutrition supplementation trial as children. Sex-specific BMI latent class trajectories were derived from 22 possible measures of height and weight from 1969 to 2004. To characterize early life determinants of BMI latent class membership, we used logistic regression modeling and estimated the difference-in-difference (DD) effect of nutrition supplementation during the first 1000 d.

Results: We identified 2 BMI latent classes in women [low (57%) and high (43%)] and 3 classes in men [low (38%), medium (47%), and high (15%)]. Nutrition supplementation during the first 1000 d after conception was not associated with BMI latent class membership (DD test: P > 0.15 for men and women), whereas higher SES was associated with increased odds of high BMI latent class membership in both men (OR: 1.98; 95% CI: 1.09, 3.61) and women (OR: 1.62; 95% CI: 1.07, 2.45) for the highest relative to the lowest tertile.

Conclusions: In a cohort of Guatemalan men and women, nutrition supplementation provided during the first 1000 d was not significantly associated with higher BMI trajectory. Higher childhood household SES was associated with increased odds of high BMI latent class membership relative to the poorest households. The pathways through which this operates still need to be explored.

Keywords: 1000 days; Guatemala; child nutrition; developmental origins; latent class growth analysis; obesity; socioeconomic status.

MeSH terms

  • Adult
  • Aging
  • Body Mass Index*
  • Child
  • Dietary Supplements
  • Female
  • Guatemala / epidemiology
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Nutritional Status
  • Pregnancy
  • Prenatal Nutritional Physiological Phenomena*
  • Rural Population*
  • Social Class
  • Socioeconomic Factors