Hip structure analysis by DXA of teriparatide treatment: A 24-month follow-up clinical study

Takeshi Mochizuki; Koichiro Yano; Katsunori Ikari; Kosei Kawakami; Ryo Hiroshima; Naoko Koenuma; Mina Ishibashi; Toshikatsu Shirahata

doi:10.1016/j.jor.2016.09.001

Hip structure analysis by DXA of teriparatide treatment: A 24-month follow-up clinical study

J Orthop. 2016 Sep 9;13(4):414-8. doi: 10.1016/j.jor.2016.09.001. eCollection 2016 Dec.

Authors

Takeshi Mochizuki¹, Koichiro Yano², Katsunori Ikari², Kosei Kawakami¹, Ryo Hiroshima¹, Naoko Koenuma¹, Mina Ishibashi¹, Toshikatsu Shirahata³

Affiliations

¹ Department of Rheumatology and Orthopaedic Surgery, Kamagaya General Hospital, Chiba, Japan.
² Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
³ Department of Orthopaedic Surgery, Chibanishi General Hospital, Chiba, Japan.

Abstract

Objective: The objective of this study was to perform a hip structure analysis (HSA) of teriparatide (TPTD) treatment in women with postmenopausal osteoporosis.

Methods: The study included 96 patients with postmenopausal osteoporosis and received 20 μg TPTD daily. HSA was performed by dual-energy X-ray absorptiometry.

Results: The percent changes from baseline for the cross-sectional moment of inertia, section modulus, buckling ratio, and femoral strength index based on HSA results were 9.8% (p < 0.01), 10.7%, 3.3%, and 14.9% (p < 0.01), respectively, at 24 months.

Conclusion: Based on the HSA results obtained with DXA, TPTD was effective for hip structures.

Keywords: Dual-energy X-ray absorptiometry; Hip structure analysis; Osteoporosis; Rheumatoid arthritis; Teriparatide.