Deeper Insights into the Allosteric Modulation of Ionotropic Glutamate Receptors

Neuron. 2016 Sep 21;91(6):1187-1189. doi: 10.1016/j.neuron.2016.09.013.

Abstract

Two articles in this issue of Neuron (Yelshanskaya et al., 2016; Yi et al., 2016) explore the structural basis of allosteric inhibition in ionotropic glutamate receptors, providing key insights into how iGluRs function in the brain as well as how they might be pharmacologically modulated in neurological disorders and disease.

MeSH terms

  • Brain*
  • Humans
  • Neurons
  • Receptors, Glutamate
  • Receptors, Ionotropic Glutamate / chemistry*

Substances

  • Receptors, Glutamate
  • Receptors, Ionotropic Glutamate