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. 2016 Nov;6(11):1201-1202.
doi: 10.1158/2159-8290.CD-NB2016-117. Epub 2016 Sep 22.

Pinpointing a Factor in Myeloma Bone Disease

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Free article

Pinpointing a Factor in Myeloma Bone Disease

No authors listed. Cancer Discov. .
Free article

Abstract

A recent study implicates thymidine phosphorylase in myeloma-induced bone disease and suggests that inhibiting the enzyme may be a viable therapeutic option. Thymidine phosphorylase provokes osteolytic lesions by disrupting the balance between bone resorption and formation, shifting it toward a net loss of bone tissue.

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