Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver

J Magn Reson Imaging. 2017 Apr;45(4):1163-1170. doi: 10.1002/jmri.25425. Epub 2016 Sep 23.


Purpose: To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (two-dimensional [2D] and 3D inversion algorithms) on liver MR elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging.

Materials and methods: Three MRE methods (EPI-MRE3D , EPI-MRE2D , and GRE-MRE2D ) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease using a 3 Tesla clinical MRI scanner, and stiffness values were compared among the three methods. A validation study comprised 73 patients with histological liver fibrosis (F0-4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3-4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D .

Results: Stiffness values of the soft and mildly stiff phantoms were 2.4 kPa and 4.0 kPa by EPI-MRE3D ; 2.6 kPa and 4.2 kPa by EPI-MRE2D ; and 2.7 kPa and 4.2 kPa by GRE-MRE2D . In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (P < 0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (P = 0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3-4) and cirrhosis (F4) (all P < 0.005).

Conclusion: EPI-MRE3D showed modestly lower liver stiffness values than conventional GRE-MRE2D . The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.

Level of evidence: 3 J. Magn. Reson. Imaging 2017;45:1163-1170.

Keywords: echo planar imaging (EPI); gradient-echo imaging (GRE); liver fibrosis staging; magnetic resonance elastography (MRE); three-dimensional postprocessing.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Echo-Planar Imaging / methods
  • Elasticity Imaging Techniques / methods*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Imaging, Three-Dimensional / methods*
  • Liver / diagnostic imaging
  • Liver Cirrhosis / diagnostic imaging*
  • Liver Cirrhosis / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Phantoms, Imaging
  • Reproducibility of Results
  • Retrospective Studies