Comparison of phytochemical profiles, antioxidant and cellular antioxidant activities of different varieties of blueberry (Vaccinium spp.)

Food Chem. 2017 Feb 15;217:773-781. doi: 10.1016/j.foodchem.2016.09.002. Epub 2016 Sep 3.


Numerous reports have demonstrated that the consumption of fruits and vegetables is beneficial for the human health. Blueberries, in particular, are rich in phytochemicals including free and bound forming. Phytochemical profiles of 14 varieties of blueberry were compared in this study. 12 compounds were analyzed and had significant changes in blueberry fruits. Total antioxidant activities in different blueberry varieties varied about 2.6times by oxygen radical absorbance capacity (ORAC) assay, and 2times by peroxyl radical scavenging capacity (PSC) assay. The cellular antioxidant activities (CAA) in different varieties varied about 3.9times without phosphate buffer saline (PBS) wash, and 4.7times with PBS wash by CAA assay. Blueberry extracts had potent antiproliferative activities against HepG2 human liver cancer cells, indicating the potential protective benefits associated with their use as functional foods. The anti-proliferative activity was observed to be dose-dependent in blueberry extracts.

Keywords: Anthocyanidin; Anti-proliferation; Antioxidant activities; Blueberry; Phytochemical profiles.

Publication types

  • Comparative Study

MeSH terms

  • Antioxidants / chemistry*
  • Antioxidants / pharmacology
  • Blueberry Plants / chemistry*
  • Blueberry Plants / classification
  • Cell Survival / drug effects
  • Fruit / chemistry*
  • Fruit / classification
  • Hep G2 Cells
  • Humans
  • Oxidation-Reduction
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology


  • Antioxidants
  • Phytochemicals
  • Plant Extracts